General Cell Based Assays
CPC Scientific Suc-Ala-Ala-Pro-Abu-pNA 1MG
ONE-LETTER SEQUENCE: Suc-AAP-Abu-pNAMOLECULAR FORMULA: C25H34N6O9MOLECULAR WEIGHT:562.57STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [108392-27-4], RESEARCH AREA: CancerREFERENCES: L. Largman, Biochemistry 22, 3763, (1983); E.G. Del Mar, et al,. Biochemistry 19, 468 ( 1980)
Revvity Health Sciences Inc HTRF Human & Mouse Total β-Catenin Detection Kit, 10,000 Assay Points
HTRF Human & Mouse Total β-Catenin Detection Kit, 10,000 Assay Points
Cayman Chemical Estradiol ELISA Kit, 480 Well
Cayman’s Estradiol ELISA Kit is a competitive assay that can be used for the quantification of estradiol in plasma and serum. This assay has a range of 0.61-10,000 pg/ml with a sensitivity of approximately 20 pg/ml (80% B/B0)
Revvity Health Sciences Inc HTRF Human & Mouse Phospho-c-Jun (Ser63) Detection Kit, 10,000 Assay Points
HTRF Human & Mouse Phospho-c-Jun (Ser63) Detection Kit, 10,000 Assay Points
Eurofins Discoverx PathHunter Sargramostim Bioassay Kit, 10pl. (93-1078Y3-00112)
The PathHunter Sargramostim Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses GM-CSF or sargramostim-induced dimerization of CSF2RB and CSF2RA receptors. This product uses EFC technology. The cell line included overexpresses CSF2RB target protein fused to PK alongside CSF2RA target protein fused to EA. Upon ligand-induced dimerization of CSF2RB and CSF2RA, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Revvity Health Sciences Inc HTRF Human Phospho-RIPK1 (Ser166) Detection Kit, 10,000 Assay Points
HTRF Human Phospho-RIPK1 (Ser166) Detection Kit, 10,000 Assay Points
Eurofins Discoverx PathHunter eXpress ACVRL1/BMPR2 Dimerization Assay, 2pl Kit. (93-0962E3CP22M)
The PathHunter ACVRL1/BMPR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. GDF2/BMP9) induced dimerization of ACVRL1/BMPR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVRL1 target protein fused to PK alongside BMPR2 target protein fused to EA. Upon ligand-induced dimerization of ACVRL1/BMPR2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GPR45 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0374E2ACP1L)
The PathHunter GPR45 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR45 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR45 and EA-tagged β-Arrestin-2. Activation of GPR45 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress NTSR1 Activated GPCR Internalization Assay, 10pl Kit. (93-0671E3CP5L)
The PathHunter NTSR1 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of NTSR1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged NTSR1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting NTSR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress MRGPRD CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0926E2CP2L)
The PathHunter MRGPRD eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. β-alanine) based activation of MRGPRD GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MRGPRD and EA-tagged β-Arrestin-2. Activation of MRGPRD stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress mCCR4 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0515E2MCP0L)
The PathHunter mCCR4 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CCL22/MDC) based activation of mCCR4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCCR4 and EA-tagged β-Arrestin-2. Activation of mCCR4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress SSTR3 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0244E2CP0L)
The PathHunter SSTR3 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. somatostatin) based activation of SSTR3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged SSTR3 and EA-tagged β-Arrestin-2. Activation of SSTR3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress OPRD1 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0108E2CP2L)
The cAMP Hunter OPRD1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. DADLE, DPDPE) based activation of OPRD1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type OPRD1, a naturally Gi/Go coupled GPCR. Upon activation of OPRD1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.